“A way to reverse CAD?” J Fam Pract 2014 Jul;63(7):356-364b.
This study was a prospective cohort of 198 self-selected, adult patients with documented coronary artery disease (CAD), cerebrovascular disease, carotid artery disease, or peripheral arterial disease (PAD) who followed a strict, plant-based dietary intervention in addition to standard medical therapy.1 The study examined compliance with diet as well as adverse cardiovascular events in both adherent and nonadherent patients.
The mean age of participants was 62.9 (SD +/- 10) and the mean study follow-up was 3.7 years. 195 (98%) of the participants had documented CAD (myocardial infarction, positive stress test, or angiography/CT angiography); the remaining patients reported cerebrovascular disease, carotid artery disease, or PAD, respectively. Of 198 who completed the study (2 had been lost to follow-up), 177 patients (89%) were determined to be compliant with the dietary intervention throughout the study course.
During the study, 13 of the 21 nonadherent patients (68%) experienced an adverse event (MI, stroke, CABG, PCI with stenting, endarterectomy, or sudden cardiac death). No nonadherent patients showed symptom improvement or disease regression.
Of the adherent patients, 18 (10%) suffered an adverse event, although 5 had were nonvascular-related deaths. Many of the other events were explained by the authors as attributed to other than advancement of vascular disease, reporting that there was only a single vascular-related adverse outcome (<0.6%) attributed to advancing disease in an adherent group (P<0.001, Fisher’s exact test). Of the 112 adherent patients who reported initial anginal symptoms, 104 showed improvement or resolution of anginal symptoms.